76ers vs. Pacers odds, prediction, betting preview, start time: NBA picks, best bets on Wednesday, Oct. 28

Best bets and betting preview for 76ers vs. Pacers on Wednesday The 76ers (3-1) visit the Pacers (2-2) on Wednesday, October 28, at Gainbridge Fieldhouse, with tipoff scheduled for 7 p.m. ET. The 76ers opened the season with three victories before losing to Detroit on Sunday. The Pacers split their latest two games, defeating Brooklyn before falling to Milwaukee. The latest 76ers vs. Pacers odds at DraftKings Sportsbook list the 76ers as 5.5-point favorites, while the Over/Under for total points scored is 236.5 points. Claim the Kalshi promo code CBSSPORTS55 here now and get a $55 bonus after $25 in trades: SportsLine's computer model has analyzed Wednesday's matchup, with Philadelphia trying to rebound from its first defeat.

Indiana has more uncertainty surrounding its lineup, with Ivica Zubac unavailable and Andrew Nembhard questionable. You can also read our NBA betting coverage for more picks and predictions. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades: Philadelphia's 3-0 start ended Sunday against Detroit, which opened on a 15-1 run and won 106-93. Tyrese Maxey scored 29 points, but the 76ers made just seven of 27 3-pointers. Joel Embiid sat out for injury management, while VJ Edgecombe also missed the game. A night earlier, Embiid banked 28 points, 11 rebounds and 10 assists in a 127-116