LSU vs. Kentucky prediction, pick, odds, spread: Tigers set for road clash with Wildcats

Kentucky, which welcomes No. 10 LSU to town on Saturday night, has lost seven straight to AP Top 25 opponents dating back to 2023 Lane Kiffin knows the next few weeks against potentially overlooked competition are must-wins for LSU if his No. 7 Tigers intend on getting to the College Football Playoff this season. That mission continues with Saturday's trip to Kentucky as a 10.5-point favorite to battle a Wildcats squad already with four wins under first-year coach Will Stein. LSU's last two trips to Lexington (2021, 2007) both ended in losses, and now, the Wildcats have renewed optimism under their new regime. Ranked at No. 24 last week, the Wildcats became the first AP Top 25 team to win on the road and be left out of the ensuing AP poll since 2012 after erasing a 17-point deficit at South Carolina to prevail in overtime — the largest road comeback in program history.

Kentucky has taken on the mentality of Stein, who rolled the dice in the extra session with a successful two-point conversion after Kenny Minchey found Willie Rodriguez in the back of the end zone. Kentucky's 2-8 over its last 10 games at home against ranked opponents, including a 0-3 mark against top-10 teams. Tigers are flexing defensively: Georgia and LSU rank Nos. 1 and 2 nationally