NFL Week 5 odds, predictions, expert picks: Who has edge in Eagles vs. Jaguars in London? Will Texans win?

CBSSports.com and SportsLine break down every single NFL game in Week 5. The 2026 NFL season has been full of surprises up to this point. Who saw the Houston Texans starting 0-4, or the Justin Herbert and Mike McDaniel marriage getting off to this rocky a start? Then, the Cleveland Browns are tied for first in the AFC North with a 3-1 record, while the Minnesota Vikings are a perfect 4-0 despite some concerns on offense. This week, the Jacksonville Jaguars and Philadelphia Eagles will battle in London. We have an NFC North showdown at Lambeau Field between the Chicago Bears and the Green Bay Packers, the San Francisco 49ers travel to play the rival Seattle Seahawks, and we get an incredible Monday night matchup between the Buffalo Bills and Los Angeles Rams.

As we do every week, we've collected all of the best picks and gambling content from CBSSports.com and SportsLine and put them in one place, so you can get sports betting picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, and more. Which picks can you make with confidence this week? And which Super Bowl contender goes down hard? Visit SportsLine, as