2026 Week 6 college football odds, spreads, betting lines, start times: Predictions, picks, best bets

SportsLine’s model has analyzed the Week 6 CFB schedule and locked in its Week 6 college football picks, predictions

The Week 6 college football schedule is absolutely loaded and before you participate in any college football betting, you'll want to check out some of the top sportsbook promos from the best betting apps. Tonight's action includes a pair of matchups featuring ranked teams, with No. 20 Iowa visiting Washington for a 9 p.m. ET kickoff and No. 8 BYU hosting Iowa State for a 10:15 p.m. ET start. The latest Week 6 college football odds list Washington (-3, 41.5) and BYU (-10.5, 46.5) as the favorites. Then on Saturday at 7:30 p.m. ET, No. 6 Alabama is favored by 1.5 at home against No. 2 Georgia with the over/under at 51.5 points.

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