Iowa State vs. BYU prediction, odds, time: Week 6 college football Friday picks from proven model

SportsLine’s model revealed its best bets for the Friday Big 12 Conference matchup between the Iowa State Cyclones and BYU Cougars

The eighth-ranked BYU Cougars will look to stay unbeaten when they battle the visiting Iowa State Cyclones in a key Big 12 Conference matchup on Friday night. Iowa State is coming off a 45-42 win over West Virginia on Saturday, while BYU held off TCU 17-10. The Cyclones (3-2, 1-1 Big 12), who are 0-2 against ranked opponents, are 0-1 on the road this season. The Cougars (4-0, 2-0 Big 12), who have outscored their opponents 149-57, are 2-0 on their home field. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 10:15 p.m.

ET at LaVell Edwards Stadium in Provo, Utah. Iowa State leads the all-time series 5-1, but BYU won last year's meeting in Iowa. The Cougars are 11.5-point favorites, with the over/under at 46.5 in the latest Iowa State vs. BYU odds. The Cougars are at -469 on the money line (risk $469 to win $100). Before making any BYU vs. Iowa State picks, check out the Iowa State vs. BYU predictions from the SportsLine Projection Model. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After simulating Iowa State vs. BYU 10,000 times, SportsLine model is going Over 45.5 points at betting apps. The