Lions vs. Cardinals odds, picks, prediction, spread, line: NFL Week 5 start time, betting preview, best bets

Here’s everything bettors need to know for Lions vs. Cardinals in NFL Week 5 action

One of the more intriguing NFL Week 5 games takes place in the desert, where the Arizona Cardinals host the Detroit Lions. The Cards are 1-3 and have dropped three straight since their win over the Chargers in Week 1, while Detroit is 2-2 after falling to Carolina in a shootout on Sunday Night Football. Neither defense has impressed this year, so this one has the makings of a high-scoring affair, if you're into that sort of thing. Kickoff from Arizona is set for 4:25 p.m. ET. DraftKings Sportsbook lists the Lions as 4.5-point favorites, and the Over/Under is set at 54.5. Spend $5+ on Lions-Cardinals in Week 5 with the latest DraftKings promo code and get $150 in bonus bets: We'll break down the latest Lions vs.

Cardinals odds from DraftKings Sportsbook and deliver our best bets for the contest with help from the SportsLine Projection Model. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. These defenses need a lot of work done. The Lions are giving