Week 6 NFL odds, picks, predictions: Computer model backs Patriots and Cardinals

SportsLine’s advanced model has simulated every game in the Week 6 NFL schedule 10,000 times and locked in its NFL best bets today

The Week 6 NFL odds feature plenty of common matchups as half of the Sunday slate consists of divisional games. Among the matchups are Ravens vs. Browns (+4.5), Patriots vs. Jets (+7.5), Rams vs. Cardinals (+12.5) and Chiefs vs. Chargers (+8.5). Kansas City is coming off a bye, which is something to keep in mind with NFL bets as the Chiefs are 1-5 ATS following their last six byes. The Panthers are the other team off a bye, and they'll face an Eagles team coming off a last-second loss in London. Even with those circumstances, Philly is a 1-point favorite per the Week 6 NFL spreads. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: The Bills are the biggest road favorite as they're giving 4.5 points to a Raiders team which took its first spread loss on Sunday to the Patriots.

There are a host of high-scoring games to make Week 6 NFL bets on in regard to the total as four matchups have an O/U of at least 50. All of the updated Week 6 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 6 NFL picks now. The