NFL Week 6 upset alert: Can Titans beat TD-favorite Colts? Will rested Bucs upset Steelers?

These favorites are not only at risk of not covering, but they could lose outright in Week 6 No matter what you think going into a given contest, the beautiful thing about the NFL is that it largely doesn't matter once the game kicks off. At that point, anything can happen, which is why the league has us in a chokehold throughout the fall. That said, as we roll along in a given season, the schedule begins to dictate where upsets could occur, simply due to the fact that one team may be a little more rested than the other, particularly as bye weeks come into play. For instance, we see that this week, between the Panthers and Eagles.

Philadelphia opened as a home favorite, but has since seen those odds flip. Why? In part, because Carolina is coming off its bye, while the Eagles are coming off an international game in London in Week 5. Even before getting into the head-to-head matchups on the rosters, that lopsided rest disparity could be a major factor. While we won't highlight that game as one of our possible upset alerts, there are some rest components we'll highlight this week as we identify five favorites who could be on the brink of a surprise loss. To steal a basketball analogy: Sometimes you just