Ohio State vs. Indiana prediction, pick, odds, spread: Buckeyes host Hoosiers in top-five showdown

No. 4 Ohio State is looking for revenge against No. 5 Indiana after last year The 100th all-time meeting between Ohio State and Indiana should be a good one. The fifth-ranked Hoosiers bring their undefeated record into Columbus for a date with the fourth-ranked Buckeyes, and the winner will have the inside track to Indianapolis. The reigning national champion, Indiana, hasn't faced a single ranked team, and it's had one of the easier schedules in the Big Ten. The Hoosiers did get a dicey road test against Nebraska last weekend, so that may have been a nice primer for what's to come on Saturday. Despite losing a number of key pieces from last year's team, Indiana still looks like a serious title contender thanks to newcomers Nick Marsh (528 receiving yards and six touchdowns), Turbo Richard (leads Big Ten in rushing yards) and Tobi Osunsanmi (leads the Big Ten in sacks and tackles for loss).

Ohio State will be looking for a little revenge after losing to Indiana in the 2025 Big Ten Championship. That loss snapped the Buckeyes' 30-game winning streak over the Hoosiers, so they'll try to start a new one on Saturday. That's entirely possible, largely due to the presence of Heisman Trophy favorite and athletic anomaly Jeremiah Smith, who leads the conference in just about every