Ole Miss vs. Missouri prediction, odds: Week 7 Saturday college football picks by proven model

SportsLine’s model has locked in its best bets for Saturday’s SEC matchup between No. 13 Missouri Tigers and No. 9 Ole Miss Rebels as Austin Simmons returns to Oxford

Missouri travels to Oxford for a compelling SEC showdown with one of the best storylines of the 2026 season, as quarterback Austin Simmons returns to Vaught-Hemingway Stadium to face the Ole Miss program he left before transferring to the Tigers. The Tigers (5-1) have been one of the SEC's biggest surprises behind Simmons and will look to keep rolling on the road, while Ole Miss (4-1) aims to make a statement at home with Simmons coming back under center. The Rebels are led by Heisman candidate Trinidad Chambliss, who took over after Simmons' departure. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 3:30 p.m.

ET at Vaught-Hemingway Stadium at Hollingsworth Field in Oxford, Miss. Missouri are 5-point underdogs in the latest Ole Miss vs. Missouri odds, with the over/under at 58.5 points. Before making any Missouri vs. Ole Miss picks, check out the Missouri vs. Ole Miss predictions from the SportsLine Projection Model. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After simulating Missouri vs. Ole Miss 10,000 times, SportsLine model is going Under 58.5 points at betting apps. The model projects a physical SEC contest in Oxford where the defenses keep the offenses in check,