Saints vs. Giants odds, picks, prediction, spread: Start time, betting preview, NFL Week 6 best bets

Here’s everything you need to know for Saints vs. Giants betting in NFL Week 6

The New Orleans Saints will face the New York Giants in Week 6 of the 2026 NFL season on Sunday. The Giants are off to a strong start despite a season-ending injury to quarterback Jaxson Dart but come in off a tie with the Commanders. New York had a chance at the victory in overtime but missed a field goal on its opening possession and then fumbled on a subsequent drive. Kickoff is set for 1 p.m. ET at MetLife Stadium. Despite their recent struggles, the visitors are 1.5-point favorites in the Saints vs. Giants odds, and the Over/Under is 46.5. Spend $5+ on Saints vs. Giants in NFL Week 6 with the latest DraftKings promo code and get a $200 bonus and 3 free months of NBA League Pass: We'll take a look at the latest Saints vs.

Giants odds at DraftKings and provide our best bet for the contest with help from the SportsLine Projection Model. The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. New