76ers vs. Knicks odds, prediction, time: 2026 NBA Opening Night picks by proven model

SportsLine’s model reveals its Philadelphia 76ers vs. New York Knicks best bets for NBA Opening Night 2026 on Tuesday as LeBron James debuts for the Sixers

The defending NBA champion New York Knicks battle LeBron James and the Philadelphia 76ers as they help tip off the 2026-27 NBA season with Opening Night on Tuesday. Philadelphia finished last season at 45-37, while New York was 53-29. The 76ers, who were swept by the Knicks in the Eastern Conference semifinals, were 22-19 on the road last season. The Knicks, who won their first NBA championship since 1972-73, were 30-10 on their home floor in 2025-26. Philadelphia revamped its roster over the offseason. Besides signing James, among their key moves was aquiring Jaylen Brown from the Celtics for Paul George and several draft picks. Visit our Kalshi promo code review and get a $55 trading bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Tipoff from Madison Square Garden in New York is set for 7 p.m.

ET. New York is a 4.5-point favorite in the latest 76ers vs. Knicks odds, while the over/under is 231.5. Before making any Knicks vs. 76ers picks, check out the 76ers vs. Knicks predictions from the SportsLine Projection Model. The SportsLine Projection Model simulates every NBA game 10,000 times and has returned nearly $19,000 in profit for $100 players on its top-rated NBA picks since 2018, including five straight seasons of four-digit profit. The model enters the 2026-27 season off yet