College football odds, picks, predictions for Week 10, 2026: Computer likes Ohio State and Oklahoma

SportsLine’s model has revealed its 2026 Week 10 college football picks today for matchups such as Miami vs. Notre Dame, LSU vs. Alabama and Georgia vs. Ole Miss

The Week 10 college football odds are filled with slim lines, which is appropriate given all of the intriguing ranked matchups. In just the SEC alone, there's Alabama vs. LSU (-5.5), Georgia vs. Ole Miss (+3.5) and Texas vs. Missouri (+2.5) to make CFB picks on at college football betting sites. Elsewhere, we're blessed with a top-5 matchup as the No. 1 Miami Hurricanes visit No. 4 Notre Dame. The Fighting Irish are 5.5-point favorites as they look to avenge last year's loss to the Canes. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Out west, the next iteration of the Holy War will take place between BYU and Utah, as the Cougars seek a fourth straight win over the Utes.

This series dates back over 100 years and has the third-ranked Utes favored by 5.5 points at home, according to the Week 10 college football spreads. Before locking in any Week 10 college football picks on these games or others, be sure to see the latest college football predictions from SportsLine's proven model. The model simulates every FBS game 10,000 times. It entered Week 10 with an 80-77 record on all top-rated college football picks at betting sites this season. Now, it has turned its attention