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College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 10 – CBS Sports

College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 10  CBS Sports Expert picks, predictions for the marquee top 25 college football games in Week 10 This is the weekend we've all…
One Place News   •   November 6, 2026   •   Updated November 6, 2026
College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 10 – CBS Sports

College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 10  CBS Sports

Expert picks, predictions for the marquee top 25 college football games in Week 10 This is the weekend we've all been waiting for this season. Preorder your food now and claim the best seat on the couch because you'll be glued to the television all day Saturday. There are seven games featuring top-25 vs. top-25 teams on Saturday. All of them have significant College Football Playoff implications. Start your day off with the Holy War in Utah when No. 9 BYU takes on No. 3 Utah (noon ET). The Utes are currently in the driver's seat in the Big 12, but BYU could shake up the race with a win over its in-state rival.

How this game shakes out could have a big impact on how many bids the Big 12 secures this season. It's a stacked weekend slate for the SEC. It starts with No. 7 Texas at No. 18 Missouri, with each a two-loss team hoping to stay in the race. No. 5 Alabama at No. 14 LSU could be a playoff eliminator, especially for the Tigers. Alabama may have enough wiggle room to survive a loss and still get in at 9-3, though Kalen DeBoer would surely prefer not to have to test that theory. LSU coach Lane Kiffin is still trying for his first career win

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