Giants vs. Rams predictions, odds, time: Week 2 'Monday Night Football' picks, NFL best bets by proven model

The SportsLine projection model has revealed its New York Giants vs. Los Angeles Rams picks for NFL Week 2 on ‘Monday Night Football’ at SoFi Stadium in Inglewood, Calif.

The New York Giants will look to continue their strong start to the season when they take on the Los Angeles Rams on 'Monday Night Football.' New York is coming off a 28-20 win over the Dallas Cowboys, while Los Angeles dropped a 27-7 decision to the San Francisco 49ers in Melbourne, Australia. Aaron Donald is set to make his return to the Rams after sitting out the opener, though Los Angeles is without Myles Garrett, who went on the IR this week with a knee injury. Puka Nacua (hip) is questionable for L.A. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Kickoff is set for 8:15 p.m.

ET from SoFi Stadium in Inglewood, Calif. The latest Giants vs. Rams odds have Los Angeles as a 6.5-point favorite, while the over/under for total points scored is 47.5. Before making any Rams vs. Giants picks or 2026 NFL Week 2 predictions, be sure to see what the SportsLine projection model has to say. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model enters Week 2 of the 2026 NFL season on a 53-39 run on top-rated picks dating back to 2024. Anybody following