Giants vs. Rams odds, predictions, NFL picks, best bets: Betting preview for Monday Night Football

Best bets and betting preview for Giants vs. Rams on Monday Night Football Week 2 of the 2026 NFL season wraps up with the Los Angeles Rams hosting the New York Giants for Monday Night Football at SoFi Stadium. The Rams began the season as the Super Bowl favorites after acquiring Myles Garrett, Trent McDuffie and Aaron Donald during the offseason, but are coming off a 27-7 loss in Australia. Meanwhile, the Giants scored a 28-20 win over the Cowboys to begin the John Harbaugh era in Week 1. Los Angeles is still favored by 6.5 in the latest Rams vs. Giants odds from FanDuel, while the over/under is 47.5 points.

Claim the best Kalshi promo code CBSSPORTS55 here now and get a $55 bonus after $25 in trades: Kickoff for Giants vs. Rams is set for 8:15 p.m. ET in Inglewood, Calif. The SportsLine Projection Model has simulated Los Angeles vs. New York 10,000 times, and SportsLine's team of NFL experts has analyzed Rams vs. Giants. Below are two best bets, and you can also read our NFL betting preview for Monday Night Football. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: After falling short in the 2026 NFC Championship Game against the Seahawks, the Rams made a heavy investment on