Cowboys vs. Buccaneers prediction, odds, time: Week 5 'Thursday Night Football' picks from advanced model

SportsLine’s model has revealed its Tampa Bay vs. Dallas picks for ‘Thursday Night Football’ in Week 5 with Baker Mayfield (thumb) still out for Tampa Bay

The Week 5 NFL schedule kicks off with a 'Thursday Night Football' matchup between NFC squads as the Dallas Cowboys host the Tampa Bay Buccaneers. Dallas moved to 2-2 with a victory over Houston in Week 4. The Bucs remain winless after falling to the Packers in Week 4 without quarterback Baker Mayfield (thumb). Mayfield is expected to remain out this week, giving rookie Jalon Daniels a second start. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 8:15 p.m. ET from AT&T Stadium in Arlington, Texas. The Cowboys have won six of their last seven home meetings with the Bucs and are 13-2 all-time at home versus Tampa.

Dallas is an 8.5-point favorite in the latest Cowboys vs. Buccaneers odds, while the over/under is 48.5. The Over is 4-0 for Dallas this season and 2-2 for the Bucs. Before making Cowboys vs. Buccaneers picks or 'Thursday Night Football' predictions, be sure to see what the SportsLine projection model has to say. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on