South Florida vs. UTSA prediction, odds, time: Week 6 college football Thursday picks by proven model

SportsLine’s model revealed its best bets for the Thursday Conference USA matchup between the South Florida Bulls and UTSA Roadrunners

The South Florida Bulls head to Texas to face one of the toughest homefield advantages in college football and the UTSA Roadrunners in a key American Athletic Conference matchup. UTSA (4-1, 1-0 AAC) is coming off a narrow 19-17 win over Rice. Coach Jeff Traylor's home record in the Alamodome is 35-5 overall and has been nearly unbeatable against conference opponents in San Antonio. Quarterback Owen McCown has been efficient with 1,010 yards and seven TDs, and Will Henderson III gives UTSA a ground game that has averaged better than five yards per carry. South Florida's (4-1, 1-1 AAC) defense has been the tighter unit, allowing 14.6 ppg, but this is its toughest challenge of the season.

The Bulls' only loss was a 17-13 stumble against Temple. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 7:30 p.m. ET at the Alamodome in San Antonio. Last year, USF rolled UTSA 55-23. The Roradrunners are 6.5-point favorites, with the over/under at 49.5 points in the latest South Florida vs. UTSA odds. The total has dropped 6 points since opening at 55.5. The Roadrunners are -250 favorites (risk $250 to win $100) on the money line. Before making any UTSA vs. South Florida picks, check out