NFL picks against the spread, Week 5 2026: Expert ATS picks, predictions, prop bets for Sunday, Oct. 11

The SportsLine experts have locked in their top Week 5 picks from this week The Week 5 NFL schedule features top contests such as Bears vs. Packers, 49ers vs. Seahawks and Ravens vs. Falcons as part of the Sunday NFL slate, leading into a potential Super Bowl preview of Bills vs. Rams on Monday Night Football. As we reach the unofficial quarter point of the 2026 NFL season, SportsLine's team of NFL experts has more reliable statistics, trends, and observations to pull from, leading to a bevy of confident plays locked in NFL picks on the Week 5 NFL schedule to use for NFL Week 5 predictions and NFL ATS picks.

The latest Week 5 NFL odds list the Bears as 2.5-point favorites against the Packers, and the Rams are 3-point favorites against the Bills on Monday Night Football with an over/under of 54.5 points, tied for the highest of the Week 5 NFL slate. Bet the NFL Week 5 with the latest FanDuel promo code and get $250 in bonus bets with a $5+ bet over five days: Whether you are looking for NFL betting advice for the nationally broadcast games, or seeking under-the-radar value from games such as Raiders vs. Patriots or Lions vs. Cardinals, you can find online sports betting picks here from SportsLine's top experts as