Eagles vs. Jaguars odds, picks, predictions: NFL London Game start time, betting preview, best bets

Here’s everything bettors need to know as Philadelphia and Jacksonville meet in an early kickoff Sunday from London’s Tottenham Hotspur Stadium

It's another early start Sunday as the NFL returns to London's Tottenham Hotspur Stadium, with the Philadelphia Eagles facing the Jacksonville Jaguars in an NFL Week 5 matchup of playoff hopefuls. The Colts beat the Commanders 30-13 on the same turf last week, and now the Jaguars will play the first of consecutive games in front of their adopted fans in London. Jacksonville comes in sitting atop the AFC South at 3-1, while the Eagles are 2-2 and sit behind the Giants in the NFC East. Kickoff is set for 9:30 a.m. ET, and Jacksonville is a 6.5-point favorite in the latest Eagles vs. Jaguars odd at DraftKings.

The Over/Under for total points scored is 42.5. Use the best Kalshi promo code CBSSPORTS55 to get a $55 bonus after $25 in trades: We have broken down down the latest Eagles vs. Jaguars odds at DraftKings Sportsbook and are now sharing insights from the SportsLine Projection Model and revealing our best bets for the showdown in London. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. It entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating to 2024. Anybody following its picks at NFL betting sites