Colts vs. Titans odds, picks, prediction, spread, line: Start time, betting preview, best bets for NFL Week 6

Here’s everything bettors need to know for Colts vs. Titans in NFL Week 6 action

The winless Tennessee Titans head north to Indianapolis to take on the Colts in Week 6 of the NFL season. It's been a dismal season for Tennessee with pressure mounting to get quarterback Cam Ward going. The Colts (2-3) come off a road loss in Pittsburgh. Kickoff for this AFC South matchup is set for 1 p.m. ET. The Colts are 7-point road favorites at DraftKings Sportsbook, and the Over/Under is 44.5. Target NFL predictions at Kalshi, where new users can get a $55 bonus with the best Kalshi promo code CBSSPORTS55: We'll break down the latest Colts vs. Titans odds from DraftKings and deliver our best bets for the contest with help from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. With all due respect to Colts and Titans fans, this is a game for the sickos. Tennessee has scored the fewest points in the NFL. They average 11.6 per game — a depressing number. This is the sort of campaign that