'Monday Night Football' prediction, odds, time: 49ers vs. Commanders picks by expert who's on 19-5 roll

Micah Roberts reveals his picks for Washington Commanders vs. San Francisco 49ers in the 2026 Week 6 ‘Monday Night Football’ matchup

Emory Hunt reveals his Commanders vs. 49ers best bets for the Week 6 After bungling the last 50-plus seconds in Sunday's overtime tie with the Giants, the Washington Commanders will look to turn their fortunes around when they take on the San Francisco 49ers in a key NFC matchup on 'Monday Night Football.' Washington was driving for the winning score in the extra session when it inexplicably ran one running play deep into New York territory and then never got another play off in the 27-27 tie. The Commanders are 0-2 on the road this season and 1-2-1 in the conference. The 49ers, meanwhile, are one of three unbeaten teams at 5-0, including a 3-0 mark against NFC foes.

Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is at 8:15 p.m. ET from Levi's Stadium in Santa Clara, Calif. The latest 49ers vs. Commanders odds have San Francisco as a 7.5-point favorite, with the over/under at 52. Before making any Commanders vs. 49ers picks, be sure to see the 'Monday Night Football' predictions from SportsLine's Micah Roberts. Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts