Guardians vs. Rays prediction, odds, time: 2026 ALCS Game 6 picks by proven model for Monday, Oct. 19

SportsLine’s model simulated Monday’s Cleveland Guardians vs. Tampa Bay Rays ALCS Game 6 matchup 10,000 times

The Tampa Bay Rays look to reach their first World Series since 2020 when they take on the Cleveland Guardians in Game 6 of the American League Championship Series on Monday night. Tampa Bay grabbed a 3-2 series lead on Sunday with a 3-1 win at Cleveland. The Guardians (85-77), who last reached the World Series in 2016, are 47-38 on the road this season, including 3-1 in the postseason. The Rays (98-64), who are one of five teams to have never won a World Series, are 58-27 on their home field in 2026, including playoffs. Freddy Peralta (10-11, 4.42 ERA) is the probable Game 6 starter for the Rays, while the Guardians haven't confirmed a starter.

Visit our Kalshi promo code review and get a $55 trading bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: First pitch for Game 6 from Tropicana Field in St. Petersburg, Fla., is set for 8:08 p.m. ET. Tampa Bay is a -148 favorite on the money line (risk $148 to win $100), while Cleveland is at +126 in the latest Guardians vs. Rays odds. The over/under is 6.5. Before making any Guardians vs. Rays picks, be sure to see the Guardians vs. Rays predictions and betting advice from SportsLine's proven computer model. SportsLine's model simulates every MLB game 10,000 times