Commanders vs. 49ers odds, prediction, betting preview, start time: Monday Night Football picks, best bets

Best bets and betting preview for Commanders vs. 49ers on Monday Night Football Week 6 of the 2026 NFL season will conclude with the San Francisco 49ers hosting the Washington Commanders on Monday Night Football. Kickoff is scheduled for 8:15 p.m. ET at Levi's Stadium in Santa Clara, Calif., and San Francisco is a perfect 5-0, while Washington is 1-3-1. The latest 49ers vs. Commanders odds list San Francisco as the 7.5-point favorite at home, and the over/under is currently 51.5. However, you can also bet dozens of NFL player props during Monday Night Football, with Christian McCaffrey priced at -265 to score a touchdown, and Terry McLaurin priced at -146 to record 4+ receptions.

Claim the Kalshi promo code CBSSPORTS55 here now and get a $55 bonus after $25 in trades: SportsLine's team of NFL experts have analyzed MNF and revealed their 49ers vs. Commanders prediction, and you can also read our NFL betting preview for Monday Night Football. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades: Kansas City already had its bye week, and Minnesota is on its bye in Week 6, so San Francisco has a chance to become the only 6-0 team in the NFL with a win on Monday. Brock Purdy has a 119.3 QB rating over