Commanders vs. 49ers prediction, odds, time: 'Monday Night Football' picks by proven model

SportsLine’s model has revealed its Washington Commanders vs. San Francisco 49ers picks for ‘Monday Night Football’

The San Francisco 49ers will look to stay perfect on the year when they take on the Washington Commanders in a key NFC matchup on 'Monday Night Football.' San Francisco defeated Seattle 32-29 in Week 5, while Washington tied the New York Giants 27-27. The Commanders (1-3-1), who are fourth in the NFC East, are 0-2 on the road this season. The 49ers (5-0), who have outscored their opponents 154-93, are 3-0 on their home field in 2026. San Francisco linebacker Dre Greenlaw has been suspended and will miss the game. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 8:15 p.m.

ET from Levi's Stadium in Santa Clara, Calif. The latest 49ers vs. Commanders odds have San Francisco as 7.5-point favorites. The over/under for total points scored is 52.5. The 49ers lead the all-time series 23-12-1, winning three of the last four. Before making any Commanders vs. 49ers picks, be sure to see the 'Monday Night Football' predictions' from SportsLine's proven model. The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 6 of the 2026 NFL season on a 57-46 run