Duke vs. Virginia prediction, odds, time: Week 8 Friday college football picks from proven model

SportsLine’s model revealed its best bets for Friday’s ACC college football matchup of the Duke Blue Devils vs. Virginia Cavaliers

Teams looking to get back into the win column clash when the Duke Blue Devils battle the Virginia Cavaliers in a key Atlantic Coast Conference matchup on Friday night. Duke is coming off a 24-20 loss to North Carolina, while Virginia dropped a 23-13 decision at SMU on Saturday. The Blue Devils (4-2, 1-2 ACC), who are tied for 11th in the conference, are 1-1 on the road this season. The Cavaliers (4-3, 2-2 ACC), who are tied for fourth in the league, are 1-1 on their home field in 2026. Virginia leads the all-time series 42-35, but Duke won the ACC Championship Game 27-20 in overtime over the Cavaliers last December.

Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 7 p.m. ET at David A. Harrison III Field at Scott Stadium in Charlottesville, Va. The Cavaliers are 2-point favorites, with the over/under at 47.5 in the latest Duke vs. Virginia odds. Before making any Duke vs. Virginia picks, check out the Duke vs. Virginia predictions from the SportsLine Projection Model. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After simulating Duke vs. Virginia 10,000 times, SportsLine model is going Over 47.5 points at betting apps.