How to bet on 2026 NFL Week 5: Betting odds, game previews, schedule, tips, trends, sportsbook promos, offers

Our NFL betting guide tells you where to bet on NFL Week 5, while providing odds, betting trends, schedule, promo offers, and more The Week 5 NFL schedule includes the first two byes of the season, as the Panthers and Chiefs will take their week off. However, there are still 15 games beginning with Cowboys vs. Buccaneers on Thursday Night Football. Baker Mayfield (thumb) remains out for the Buccaneers, and the Cowboys are favored by 9.5 in the latest Week 5 NFL odds with the over/under at 47.5. There are also five important divisional rivalry games on Sunday, including Packers vs. Bears and Seahawks vs. 49ers. Get $150 in bonus bets after making a $5 wager with the latest DraftKings promo code: Chicago has won two in a row with backups Case Keenum and Tyson Bagent, and the Bears are favored by 3 on the road over the Packers with the over/under at 45 points.

Meanwhile, first place in the NFC West will be on the line in Seattle, where the Seahawks are favored by 3 points at home and the over/under is 47. Then, in a potential Super Bowl preview on Monday Night Football, the Rams are favored by 2.5 at home over the Bills, while the over/under is 54.5 points. Our Week 5 NFL betting guide highlights many