Iowa State vs. BYU odds, picks, predictions, best bets, start time for Week 6 college football Friday

A pair of Big 12 squads clash Friday night with the undefeated Cougars hosting the Cyclones The BYU Cougars will try to take another step towards making the College Football Playoff when they host the Iowa State Cyclones on Friday night in Big 12 action. The Cougars had a great 12-2 season in 2025, but both loses came to Texas Tech and they missed out on the CFP. The Red Raiders don't look quite as potent this year, so the Cougars may have a better chance of reaching the CFP. The Cyclones have a new look this year as longtime head coach Matt Campbell left Ames for Penn State after 10 seasons at the helm.

New head coach Jimmy Rogers is leading the way now after formerly leading South Dakota State and Washington State. Iowa State is off to a 3-2 start so far, losing to rival Iowa and undefeated Utah. Kickoff is set for 10:15 p.m. ET in Provo, Utah, and BYU is a 10.5-point favorite per the latest Iowa State vs. BYU odds. Bet on Iowa State vs. BYU in Week 6 at DraftKings and get $150 in bonus bets when you spend $5+: The Cougars and Cyclones clashed in Ames last year, with BYU taking home a 41-27 shootout win. The Cougars return many of their star