Knicks vs. Celtics prediction, odds, betting preview, start time: NBA picks, best bets on Friday, Oct. 23

Best bets and betting preview for Celtics vs. Knicks on Friday The 2026-27 NBA opening week continues with the Boston Celtics hosting the New York Knicks in an Eastern Conference showdown on Friday night. The defending NBA champion Knicks and a Celtics team always in the championship mix look to bounce back from opening night losses on Tuesday. The Celtics are 2.5-point home favorites in the latest Knicks vs. Celtics odds, with the over/under at 220.5 points. Claim the Kalshi promo code CBSSPORTS55 here now and get a $55 bonus after $25 in trades: Tipoff for Celtics vs. Knicks is set for 7 p.m. ET at TD Garden in Boston, Massachusetts.

SportsLine's proven computer model has analyzed Knicks vs. Celtics and revealed its Celtics vs. Knicks prediction, and you can also read our NBA betting preview for Friday's matchup. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades: Opening Night for the defending champions is always a chaotic evening, with the pomp and circumstance around the ring ceremonies, banner raising and overall looking back at the year that was. On Friday, it's strictly about on-court basketball for the Knicks in Boston after their 106-100 loss to the 76ers on Opening Night. The Knicks returned nearly their entire rotation from last year's championship squad,