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NBA DFS: Top DraftKings, FanDuel daily Fantasy basketball picks for Wednesday, Oct. 21 include Jalen Johnson

SportsLine’s Mike McClure, a daily Fantasy pro with more than $2 million in winnings, gives optimal NBA DFS lineup advice for Wednesday DFS millionaire Mike McClure reveals his daily Fantasy basketball picks for FanDuel and DraftKings on Wednesday,…
One Place News   •   October 21, 2026   •   Updated October 21, 2026
NBA DFS: Top DraftKings, FanDuel daily Fantasy basketball picks for Wednesday, Oct. 21 include Jalen Johnson

SportsLine’s Mike McClure, a daily Fantasy pro with more than $2 million in winnings, gives optimal NBA DFS lineup advice for Wednesday

DFS millionaire Mike McClure reveals his daily Fantasy basketball picks for FanDuel and DraftKings on Wednesday, Oct. 21 The NBA's Opening Week continues on Wednesday, which has 22 teams taking the court. Thus, there's a much deeper NBA DFS player pool than Tuesday, which featured just three games as the likes of Anthony Edwards, Zion Williamson, Kevin Durant and Cooper Flagg will make their season debuts. Also, Giannis Antetokounmpo, LaMelo Ball and Ja Morant will be making team debuts, providing an abundance of options for NBA DFS lineups. Luka Doncic is the most expensive player on both DraftKings and FanDuel as the Lakers start the post-LeBron James era by hosting Steph Curry and the Warriors.

Knowing which players justify their high costs and knowing which are better kept our of daily Fantasy basketball lineups should be a part of your Wednesday NBA DFS strategy. Before making any NBA DFS picks, be sure to check out the NBA DFS advice, player rankings, stacks, and top daily Fantasy basketball picks from SportsLine's Mike McClure. McClure is a DFS professional with more than $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account. This allows

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