NFL Week 5 injury report: Eagles' Saquon Barkley and DeVonta Smith out, Bears' Caleb Williams questionable

Here’s a look at the game designations for Week 5 in the NFL

Week 5 of the 2026 NFL season is almost here and teams are sending out their final injury reports for the week in preparation for the upcoming matchups. Injuries have plagued this season already and each week it seems we are seeing a top player go down. Teams have needed to restructure and make new plans as key players are unavailable, with numerous quarterbacks out. This week, Bears QB Caleb Williams is questionable and could make his return, while QB Jayden Daniels is good to go. This week, the Chiefs and Panthers are on a bye, so they have some time to get healthy for Week 6. Here's a look at the final injury reports for Sunday: The already struggling Eagles will be without star running back Saquon Barkley, who suffered a hamstring injury during last week's loss to the Rams.

The offense will also be without WR DeVonta Smith. The Jags are relatively healthy heading into their annual London game, with just two players with designations this week. CB Jaylon Jones was ruled out with a hamstring injury, despite being limited in practice all week, and Eric Murray is doubtful after being limited for the last two days of practice. The Bears have a chance to get their starting quarterback back on the field this week, after missing Caleb