Rams vs. Bills odds, prediction, betting preview, start time: Monday Night Football picks, best bets

Best bets and betting preview for Bills vs. Rams on Monday Night Football The Los Angeles Rams will host the Buffalo Bills for Monday Night Football to conclude Week 5 of the 2026 NFL season. Matthew Stafford and Josh Allen are the last two NFL MVPs, and the two quarterbacks will go head-to-head in a potential Super Bowl preview. The Rams (2-2) began the year as title favorites but were up and down in their first month of the season, while the Bills (3-1) are coming off their first loss of the season to the Patriots. The latest Rams vs. Bills odds list Los Angeles as the 3.5-point favorite at home, and the over/under is 54.5 points.

Stafford's over/under for total passing yards is 282.5, while Allen to record 2+ passing touchdowns is priced at -104. Claim the Kalshi promo code CBSSPORTS55 here now and get a $55 bonus after $25 in trades: Kickoff for Bills vs. Rams is set for 8:15 p.m. ET at SoFi Stadium in Inglewood, Calif. SportsLine's team of NFL experts have analyzed MNF and revealed their Rams vs. Bills prediction, and you can also read our NFL betting preview for Monday Night Football. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades: The Rams remain Super Bowl favorites