Week 5 NFL picks, best bets from proven model: This 5-leg parlay pays nearly 25-1

After 10,000 simulations, SportsLine’s model reveals its top Week 5 NFL parlay

The Houston Texans have stumbled out of the gates and look to earn their first win of the season when they battle the Tennessee Titans in an AFC South matchup in one of several must-win situations to highlight the NFL Week 5 schedule. Another team in need of a win is the Los Angeles Rams, a Super Bowl pick that finds themselves two games out in the highly-competitive NFC West race. The Rams avoided a 1-3 start with a 24-20 win over the Philadelphia Eagles this past Sunday. The Rams enter as 2.5-point home favorites when they entertain the Buffalo Bills on 'Monday Night Football.' Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: There are a number of intriguing matchups in Week 5, including 49ers vs.

Seahawks (-3) in another game involving NFC West foes. Other top games include Ravens vs. Falcons (+2.5) on 'Sunday Night Football,' with Lamar Jackson (ankle) doubtful, Bears vs. Packers (+3), which has Caleb Williams (hamstring) unlikely to play, Colts vs. Steelers (-2.5) and Broncos vs. Chargers (+3.5). The Chargers are seeking to avoid their first 0-5 start since 2003. Before locking in any Week 5 NFL picks, be sure to see the NFL parlay and betting advice from SportsLine's proven computer