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NFL Week 5 upset alert: Why these five favorites could easily lose, including the Patriots

After accurately identifying three major upsets last week, we examine five more for Week 5. No favorite appears to be safe these days in the NFL, as underdogs have come on strong over the first month of the…
One Place News   •   October 8, 2026   •   Updated October 8, 2026
NFL Week 5 upset alert: Why these five favorites could easily lose, including the Patriots

After accurately identifying three major upsets last week, we examine five more for Week 5. No favorite appears to be safe these days in the NFL, as underdogs have come on strong over the first month of the regular season. In the past two weeks, a total of 23 games have been decided by one score, which is tied for the most in a two-week span in NFL history. Naturally, those coin-flip games have produced quite a bit of upsets, and we've largely been on the scent with them. In last week's upset alert, we accurately identified the Texans, Lions, and Saints as favorites ripe to fall short, with the Cowboys, Panthers, and Falcons each pulling off upsets.

Now, we turn our focus to Week 5, where there are several home underdogs, which always put our antenna up. Three of which you can find below, as they could stun the road favorites this weekend, along with two AFC East favorites possibly on shaky ground at home. New England is coming off its biggest win of the season after going up to Buffalo and upsetting the Bills to get to 2-2 on the year. After it felt like the sky was falling in Foxborough, that win — at least for the moment — stabilized things. That said, this does feel like

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This One Place News story was acquired from cbssports.com. OPN retains the source link and provenance for newsroom review.

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