Florida State vs. Louisville prediction, odds, time: Week 6 college football Friday picks from proven model

SportsLine’s model revealed its best bets for the Friday Atlantic Coast Conference matchup featuring the Florida State Seminoles vs. Louisville Cardinals

The Florida State Seminoles will look to make it three wins in a row when they take on the Louisville Cardinals in a key Atlantic Coast Conference matchup on Friday night. Florida State is coming off a 38-7 win over Virginia in Week 5, while Louisville dropped a 31-28 decision at North Carolina State. The Seminoles (3-2, 1-1 ACC), who have won two in a row, are 0-1 on the road this season. The Cardinals (2-3, 1-2 ACC), who have dropped two consecutive games, are 2-1 on their home field in 2026. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 7 p.m.

ET at L&N Federal Credit Union Stadium in Louisville, Ky. Florida State leads the all-time series 18-6, including two wins in a row. The Cardinals are 3.5-point favorites, with the over/under at 59.5 in the latest Florida State vs. Louisville odds. Both teams are 3-2 against the spread this season. Before making any Louisville vs. Florida State picks, check out the Florida State vs. Louisville predictions from the SportsLine Projection Model. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After simulating Florida State vs. Louisville 10,000 times, SportsLine model is going Under 59.5 points