White Sox vs. Guardians prediction, odds, time: 2026 MLB ALDS Game 5 picks from advanced model

SportsLine’s model simulated Cleveland Guardians vs. Chicago White Sox 10,000 times and revealed its MLB picks for Saturday’s AL Division Series Game 5 matchup

A spot in the American League Championship Series is on the line when the Chicago White Sox battle the Cleveland Guardians in Game 5 of the ALDS on Saturday night. Cleveland evened the series with a 9-5 win on Thursday. The White Sox (84-78), who finished second in the AL Central, are 38-45 on the road in 2026, including the postseason. The Guardians (85-77), who won the AL Central, are 41-42 at home. Chicago is expected to start right-hander Sean Burke (11-7, 3.34 ERA), while Cleveland is expected to counter with right-hander Gavin Williams (14-8, 3.76 ERA). Visit our Kalshi promo code review and get a $55 trading bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: First pitch from Progressive Field in Cleveland is set for 8 p.m.

ET. Cleveland is a -138 favorite on the money line (risk $138 to win $100) in the latest White Sox vs. Guardians odds, while the over/under is 7. The Over has hit in six of the last seven matchups between the teams. Before making any Guardians vs. White Sox picks, be sure to see the White Sox vs. Guardians predictions and betting advice from SportsLine's proven computer model. SportsLine's model simulates every MLB game 10,000 times and enters the divisional round of the 2026 MLB playoffs on a 31-25