College football odds, picks, predictions for Week 4, 2026: Computer likes Colorado, USC

SportsLine’s model has revealed its 2026 Week 4 college football picks for Texas vs. Tennessee, LSU vs. Texas A&M and every other game

The Week 4 college football schedule is when conference play officially kicks off for many teams. The Big Ten features the likes of USC vs. Oregon (-3) and Michigan vs. Iowa (+4.5) to make Week 4 college football picks on, with the SEC offering Texas vs. Tennessee (-3.5), with Colorado vs. Baylor (-10) over in the Big 12. Elsewhere, Notre Dame vs. Purdue is always a hotly contested in-state rivalry as the two Battle for the Shillelagh Trophy in their 90th all-time meeting, with the Irish, who are favored by 27.5 points, having won each of the last eight matchups. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: Speaking of in-state matchups, Carolinians will look forward to NC State vs.

App State (+14), with the Wolfpack looking to rebound after a shocking last-second defeat to Vanderbilt. Meanwhile, one of the largest Week 4 college football spreads has the Miami Hurricanes favored by 41.5 points over Central Michigan. Before locking in any Week 4 college football picks, be sure to see the latest college football predictions from SportsLine's proven model. The model simulates every FBS game 10,000 times. It is off to a profitable 22-19 start on all top-rated college football picks at betting sites so far this season, and it has been