Week 5 NFL odds, picks, predictions: Computer model backs Vikings and Bengals

SportsLine’s advanced model has simulated every game in the Week 5 NFL schedule 10,000 times and locked in its NFL best bets today

The Week 5 NFL schedule has just one game featuring teams over .500 versus one another. Seahawks vs. 49ers has Seattle favored by 3 points at home, per the Week 5 NFL odds, while there's a litany of matchups pitting teams without winning records against each other. Chief among them is Texans vs. Titans (+7) as both squads are winless. Others include Steelers vs. Colts (+2.5), Lions vs. Cardinals (+5.5) and Bengals vs. Dolphins (+7.5) as Miami is, again, the biggest Sunday underdog according to the latest Week 5 NFL lines. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Colts vs.

Steelers has a rather slim NFL spread, considering that Indy is coming off a trip from London, while Pittsburgh is coming off a Thursday game and mini-bye. Speaking of byes, this is the first slate of games with them, and without 16 games to make Week 5 NFL predictions on, you can devote more time, effort and bets on a smaller register of matchups. All of the updated Week 5 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 5 NFL picks now. The model, which simulates every NFL