LSU vs. Kentucky prediction, odds, time: Week 6 college football picks from proven model

SportsLine’s model has locked in its best bets for Saturday’s matchup of the LSU Tigers vs. Kentucky Wildcats

LSU travels to Lexington for a massive SEC showdown Saturday night when the Tigers take on Kentucky in a battle between two teams sitting at 4-1. The Tigers are coming off a dominant 63-14 blowout of McNeese in Week 5, with quarterback Sam Leavitt throwing three touchdown passes in the rout, and enter as 8.5-point road favorites. Kentucky has been one of the SEC's best stories in 2026 on the strength of a strong home record and the steady play of quarterback Kenny Minchey. This is a pivotal conference game for both programs' SEC title hopes. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: Kickoff is set for 7 p.m.

ET at Kroger Field in Lexington, Ky. The Tigers are 8.5-point favorites in the latest LSU vs. Kentucky odds, while the over/under is 50.5 points. Before making any Kentucky vs. LSU picks, check out the LSU vs. Kentucky predictions from the SportsLine Projection Model. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After simulating LSU vs. Kentucky 10,000 times, SportsLine model is going Under 50.5 points at betting apps. Kentucky has been one of the more defense-minded teams in the SEC this season, and despite LSU's dominant Week 5 outing