Guardians vs. White Sox prediction, odds, time: 2026 MLB ALDS Game 4 picks for Thursday, Oct. 8, by model

SportsLine’s model simulated Cleveland Guardians vs. Chicago White Sox 10,000 times and revealed its MLB picks for Thursday’s AL Division Series Game 4 matchup

The Cleveland Guardians will look to even their best-of-five series with the Chicago White Sox when they meet in Game 4 of their American League Division Series on Thursday. Cleveland avoided being swept by posting a 9-3 win on Wednesday. The Guardians (85-77), who won the AL Central, are 45-37 on the road this season, including the postseason. The White Sox (84-78), who finished second in the AL Central, are 48-34 on their home field in 2026. Cleveland is expected to start left-handed pitcher Parker Messick (12-9, 2.56 ERA), while Chicago is expected to counter with Hagen Smith (3-3, 1.29 ERA). Visit our Kalshi promo code review and get a $55 trading bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: First pitch from Guaranteed Rate Field in Chicago is set for 8 p.m.

ET. Cleveland is a -112 favorite on the money line (risk $112 to win $100) in the latest Guardians vs. White Sox odds, while the over/under, is 7.5. The Over has hit in five of the last six matchups between the teams. Before making any White Sox vs. Guardians picks, be sure to see the Guardians vs. White Sox predictions and betting advice from SportsLine's proven computer model. SportsLine's model simulates every MLB game 10,000 times and enters the divisional round of the 2026