Hidden gut defect that may explain why IBD keeps coming back

Researchers have uncovered a hidden molecular warning sign of inflammatory bowel disease (IBD) that can linger even when patients feel well and appear to be in remission. By studying around 900 human gut biopsies and patient-derived mini-intestines, the team found that intestinal cells can remain unusually primed to die, creating a “smoldering” defect that may help drive future flare-ups. Researchers have identified early molecular warning signs of inflammatory bowel disease that may appear before symptoms and remain active even when patients seem to be doing well. The study, led by WEHI in partnership with the Royal Melbourne Hospital, uncovered a hidden defect in intestinal cells that can make them vulnerable to damage.

The problem was still detectable in some patients whose disease appeared to be well controlled. Published in Science, the findings may help explain why people with inflammatory bowel disease can experience sudden flare-ups even after reaching remission. WEHI researchers identified a 'smoldering' molecular defect in gut cells from people with inflammatory bowel disease. The defect involves abnormal cell death and could be detected even in patients whose disease was under good control. The work, carried out through a broad collaboration with the Royal Melbourne Hospital, could eventually lead to earlier