Vikings vs. Saints odds, picks, prediction, spread, line: NFL Week 5 start time, betting preview, best bets

Here’s everything bettors need to know for Vikings vs. Saints in NFL Week 5 action

The Minnesota Vikings are 4-0 heading into their Week 5 showdown against the New Orleans Saints, overcoming injuries at quarterback and receiver in two of their wins. Kyler Murray is back under center, and star receiver Justin Jefferson says he plans to play in what is effectively a return to his hometown in New Orleans, though he and fellow wideout Jordan Addison are listed as questionable. The Saints are coming into Week 5 after being embarrassed on Monday Night Football on the 20th anniversary of the return to the Superdome at the hands of their rivals, the Atlanta Falcons. Can New Orleans turn things around in Week 5, or will the Vikings remain undefeated?

Kickoff from the Superdome in New Orleans is set for 1 p.m. ET. Use the latest DraftKings promo code to get $150 in bonus bets when you spend $5+ on Vikings vs. Saints: Here's everything you need to know for Vikings vs. Saints, with odds from DraftKings Sportsbook and our best bet for the contest using data from the SportsLine Projection Model. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks