Giants vs. Commanders odds, picks, prediction, spread, line: NFL Week 5 start time, betting preview, best bets

Here’s everything bettors need to know for Giants vs. Commanders in NFL Week 5 action

Two NFC East squads face off on Sunday, Oct. 11, in Week 5 of the 2026 NFL season when the New York Giants head to the nation's capital to face the Washington Commanders. The Giants have lost quarterback Jaxson Dart for the season but have a one-game lead in the division while the Commanders appear to be getting their top quarterback Jayden Daniels back for this clash. Kickoff from Northwest Stadium is set for 1 p.m. ET. Spend $5+ on Giants vs. Commanders in NFL Week 5 using the latest DraftKings promo code to get $150 in bonus bets: We'll take a look at the latest Giants vs. Commanders odds from DraftKings Sportsbook and highlight our best bet for the contest with insight from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. Jameis Winston has taken over for Dart at quarterback but the real story for New York is how the defense has played. The Giants rank eighth in points allowed per game,